About us

The Laboratory of Cancer Epigenetics led by François Fuks aims to investigate mechanisms underlying epigenetic modifications and how they go awry in cancer (see Research interests for more details).

I. A current main focus of the lab is the study of a novel pillar of epigenetics, termed RNA epigenetics (Delatte et al., Science 2016).

II. Heretofore, we have been interested in studying DNA modifications (DNA methylation and hydroxymethylation) during the processes of transcription and the deregulated signaling endows transcription in cancers.

III. Besides studying fundamental mechanisms of cancer epigenetics, there is growing interest from our lab in cancer epigenomics. In this respect, we are heading a high throughput sequencing platform dedicated to epigenetics: EPICS - EPIgenomic Creative Solutions.

The Laboratory is part of the ULB-Cancer Research Center (U-CRC) gathering scientists working in cutting edge cancer research areas (basic, translational and clinical).

Selected Publications

• Jeschke J et al. (2017) J Clin Invest.
  
  
• Delatte B et al. (2016) Science
  
  
• Larsimont JC et al. (2015) Cell Stem Cell.
  
  
• Uribe-Lewis S et al. (2015) Genome Biol.
  
  
• Deplus R et al. (2014) Cell Rep.
  
  
• Boumahdi S et al.(2014) Nature
  
  
• Delatte B et al. (2014) EMBO J.
  
  
• Deplus R et al. (2013) EMBO J.
  
  
• Volkmar M al. (2012) EMBO J.
  
  
• Dedeurwaerder S al. (2011) EMBO Mol. Med.
  
  
• Viré E et al. (2006) Nature